Cargando…

Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)

Structure–activity relationship studies were conducted on Irosustat (STX64, BN83495), the first steroid sulfatase (STS) inhibitor to enter diverse clinical trials for patients with advanced hormone-dependent cancer. The size of its aliphatic ring was expanded; its sulfamate group was N,N-dimethylate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woo, L W Lawrence, Ganeshapillai, Dharshini, Thomas, Mark P, Sutcliffe, Oliver B, Malini, Bindu, Mahon, Mary F, Purohit, Atul, Potter, Barry V L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2011
Materias:	Full Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262147/ https://www.ncbi.nlm.nih.gov/pubmed/21990014 http://dx.doi.org/10.1002/cmdc.201100288

Ejemplares similares

C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors
por: Ganeshapillai, Dharshini, et al.
Publicado: (2018)

Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2023)

Inhibition of Steroid Sulfatase Activity in Endometriotic Implants by STX64 (667Coumate): A Potential New Therapy
por: Fusi, L., et al.
Publicado: (2008)

IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer
por: Palmieri, Carlo, et al.
Publicado: (2017)

Aromatase and Dual Aromatase-Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates
por: Wood, Paul M, et al.
Publicado: (2011)

IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients
por: Palmieri, Carlo, et al.
Publicado: (2017)

Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors
por: El-Gamal, Mohammed I., et al.
Publicado: (2016)

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases
por: Rižner, Tea Lanišnik
Publicado: (2016)

Sulfatase 2 Is Associated with Steroid Resistance in Childhood Nephrotic Syndrome
por: Agrawal, Shipra, et al.
Publicado: (2021)

Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty
por: Idkowiak, Jan, et al.
Publicado: (2016)

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer
por: Stengel, C, et al.
Publicado: (2014)

Synthesis and Structure–Activity Relationship Studies of Derivatives of the Dual Aromatase–Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate
por: Woo, L W Lawrence, et al.
Publicado: (2013)

The Role of Steroid Sulfatase as a Prognostic Factor in Patients with Endometrial Cancer
por: Lee, Won Moo, et al.
Publicado: (2016)

Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells
por: Ye, Dong-Jin, et al.
Publicado: (2017)

Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER
por: Gilligan, Lorna C., et al.
Publicado: (2017)

Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder
por: Stergiakouli, E, et al.
Publicado: (2011)

Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells
por: Ropero, Ana B., et al.
Publicado: (2012)

Converging Pharmacological and Genetic Evidence Indicates a Role for Steroid Sulfatase in Attention
por: Davies, William, et al.
Publicado: (2009)

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
por: Pérez-Jiménez, Mercedes M., et al.
Publicado: (2021)

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure
por: Day, J M, et al.
Publicado: (2009)

Mechanisms that Determine the Differential Stability of Stx(+) and Stx(−) Lysogens
por: Colon, Michael P., et al.
Publicado: (2016)

Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells
por: Ropero, Ana B., et al.
Publicado: (2012)

The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer
por: Parsons, M F C, et al.
Publicado: (2008)

Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder
por: Trent, Simon, et al.
Publicado: (2012)

In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics
por: McNamara, Keely M, et al.
Publicado: (2018)

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin
por: Bunger, Joshua C., et al.
Publicado: (2015)

Sulfatase 1 and sulfatase 2 as novel regulators of macrophage antigen presentation and phagocytosis
por: Kim, Hyun-Je, et al.
Publicado: (2021)

Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer
por: Shimizu, Yasuomi, et al.
Publicado: (2018)

Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy
por: Gilligan, Lorna C., et al.
Publicado: (2017)

Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer
por: Mungenast, Felicitas, et al.
Publicado: (2017)

Identification and Characterization of ten Escherichia coli Strains Encoding Novel Shiga Toxin 2 Subtypes, Stx2n as Well as Stx2j, Stx2m, and Stx2o, in the United States
por: Lindsey, Rebecca L., et al.
Publicado: (2023)

Detection of stx(1) and stx(2) Genes in Pennsylvanian White-Tailed Deer
por: Kistler, Whitney M., et al.
Publicado: (2011)

Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing Escherichia coli (STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice
por: McNichol, Beth A., et al.
Publicado: (2021)

Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice
por: Sheoran, Abhineet, et al.
Publicado: (2012)

Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study
por: Poisson Paré, D., et al.
Publicado: (2009)

SUN-LB003 The Steroid Sulfatase Dictates the Hormone Replacement Therapy Efficacy of the Conjugated Equine Estrogen
por: Feng, Ye, et al.
Publicado: (2019)

Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors
por: Calvillo-Robledo, Argelia, et al.
Publicado: (2021)

Quantification of the enzyme activities of iduronate-2-sulfatase, N-acetylgalactosamine-6-sulfatase and N-acetylgalactosamine-4-sulfatase using liquid chromatography-tandem mass spectrometry
por: Mashima, Ryuichi, et al.
Publicado: (2017)

New Stx2e Monoclonal Antibodies for Immunological Detection and Distinction of Stx2 Subtypes
por: Skinner, Craig, et al.
Publicado: (2015)

Differences in the Shiga Toxin (Stx) 2a Phage Regulatory Switch Region Influence Stx2 Localization and Virulence of Stx-Producing Escherichia coli in Mice
por: Atitkar, Rama R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lvkht372510hj79r7507u8rqqp