Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostin

INTRODUCTION: Breast cancers frequently metastasise to the skeleton where they cause osteolytic bone destruction by stimulating osteoclasts to resorb bone and by preventing osteoblasts from producing new bone. The Runt-related transcription factor 2, Runx2, is an important determinant of bone metast...

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Detalles Bibliográficos
Autores principales: Mendoza-Villanueva, Daniel, Zeef, Leo, Shore, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262219/
https://www.ncbi.nlm.nih.gov/pubmed/22032690
http://dx.doi.org/10.1186/bcr3048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262219/
https://www.ncbi.nlm.nih.gov/pubmed/22032690
http://dx.doi.org/10.1186/bcr3048

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