Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole

BACKGROUND: Many medicines, including several cholesterol-lowering agents (eg, lovastatin, simvastatin), antihypertensives (eg, diltiazem, nifedipine, verapamil), and antifungals (eg, ketoconazole) are metabolized by and/or inhibit the cytochrome P450 (CYP) 3A4 metabolic pathway. These types of medi...

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Detalles Bibliográficos
Autores principales: Patel, Chirag G, Li, Li, Girgis, Suzette, Kornhauser, David M, Frevert, Ernest U, Boulton, David W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262391/
https://www.ncbi.nlm.nih.gov/pubmed/22287853
http://dx.doi.org/10.2147/CPAA.S15227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262391/
https://www.ncbi.nlm.nih.gov/pubmed/22287853
http://dx.doi.org/10.2147/CPAA.S15227

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