Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongl...

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Detalles Bibliográficos
Autores principales: Saha, Manujendra N., Jiang, Hua, Yang, Yijun, Zhu, Xiaoyun, Wang, Xiaoming, Schimmer, Aaron D., Qiu, Lugui, Chang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262803/
https://www.ncbi.nlm.nih.gov/pubmed/22276160
http://dx.doi.org/10.1371/journal.pone.0030215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262803/
https://www.ncbi.nlm.nih.gov/pubmed/22276160
http://dx.doi.org/10.1371/journal.pone.0030215

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