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Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPARγ
Impairments in mitochondria and transcription are important factors in the pathogenesis of Huntington disease (HD), a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. This study investigated the effect of different metabolic states and peroxisome proliferator-...
Autores principales: | Jin, Youngnam N., Hwang, Woong Y., Jo, Chulman, Johnson, Gail V. W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262812/ https://www.ncbi.nlm.nih.gov/pubmed/22276192 http://dx.doi.org/10.1371/journal.pone.0030406 |
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