p38α signaling programs dendritic cells to drive T(H)17 cell differentiation and autoimmune inflammation

Dendritic cells (DCs) bridge innate and adaptive immunity, but how DC-derived signals regulate T cell lineage choices remains unclear. We report that p38α MAP kinase programs DCs to drive T(H)17 differentiation. Deletion of p38α in DCs, but not macrophages or T cells, protects mice from T(H)17-media...

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Detalles Bibliográficos
Autores principales: Huang, Gonghua, Wang, Yanyan, Vogel, Peter, Kanneganti, Thirumala-Devi, Otsu, Kinya, Chi, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262925/
https://www.ncbi.nlm.nih.gov/pubmed/22231518
http://dx.doi.org/10.1038/ni.2207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262925/
https://www.ncbi.nlm.nih.gov/pubmed/22231518
http://dx.doi.org/10.1038/ni.2207

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