Cargando…
p38α signaling programs dendritic cells to drive T(H)17 cell differentiation and autoimmune inflammation
Dendritic cells (DCs) bridge innate and adaptive immunity, but how DC-derived signals regulate T cell lineage choices remains unclear. We report that p38α MAP kinase programs DCs to drive T(H)17 differentiation. Deletion of p38α in DCs, but not macrophages or T cells, protects mice from T(H)17-media...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262925/ https://www.ncbi.nlm.nih.gov/pubmed/22231518 http://dx.doi.org/10.1038/ni.2207 |