Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model

Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimer’s Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregati...

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Detalles Bibliográficos
Autores principales: Martin, Sarah B, Dowling, Amy L.S, Head, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263459/
https://www.ncbi.nlm.nih.gov/pubmed/22654723
http://dx.doi.org/10.2174/157015911798376217
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author Martin, Sarah B
Dowling, Amy L.S
Head, Elizabeth
author_facet Martin, Sarah B
Dowling, Amy L.S
Head, Elizabeth
author_sort Martin, Sarah B
collection PubMed
description Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimer’s Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting Aβ.
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spelling pubmed-32634592012-06-01 Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model Martin, Sarah B Dowling, Amy L.S Head, Elizabeth Curr Neuropharmacol Article Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimer’s Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting Aβ. Bentham Science Publishers 2011-12 /pmc/articles/PMC3263459/ /pubmed/22654723 http://dx.doi.org/10.2174/157015911798376217 Text en ©2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Martin, Sarah B
Dowling, Amy L.S
Head, Elizabeth
Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
title Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
title_full Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
title_fullStr Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
title_full_unstemmed Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
title_short Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model
title_sort therapeutic interventions targeting beta amyloid pathogenesis in an aging dog model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263459/
https://www.ncbi.nlm.nih.gov/pubmed/22654723
http://dx.doi.org/10.2174/157015911798376217
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