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cGMP Signaling, Phosphodiesterases and Major Depressive Disorder

Deficits in neuroplasticity are hypothesized to underlie the pathophysiology of major depressive disorder (MDD): the effectiveness of antidepressants is thought to be related to the normalization of disrupted synaptic transmission and neurogenesis. The cyclic adenosine monophosphate (cAMP) signaling...

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Autores principales: Reierson, Gillian W, Guo, Shuyu, Mastronardi, Claudio, Licinio, Julio, Wong, Ma-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263465/
https://www.ncbi.nlm.nih.gov/pubmed/22654729
http://dx.doi.org/10.2174/157015911798376271
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author Reierson, Gillian W
Guo, Shuyu
Mastronardi, Claudio
Licinio, Julio
Wong, Ma-Li
author_facet Reierson, Gillian W
Guo, Shuyu
Mastronardi, Claudio
Licinio, Julio
Wong, Ma-Li
author_sort Reierson, Gillian W
collection PubMed
description Deficits in neuroplasticity are hypothesized to underlie the pathophysiology of major depressive disorder (MDD): the effectiveness of antidepressants is thought to be related to the normalization of disrupted synaptic transmission and neurogenesis. The cyclic adenosine monophosphate (cAMP) signaling cascade has received considerable attention for its role in neuroplasticity and MDD. However components of a closely related pathway, the cyclic guanosine monophosphate (cGMP) have been studied with much lower intensity, even though this signaling transduction cascade is also expressed in the brain and the activity of this pathway has been implicated in learning and memory processes. Cyclic GMP acts as a second messenger; it amplifies signals received at postsynaptic receptors and activates downstream effector molecules resulting in gene expression changes and neuronal responses. Phosphodiesterase (PDE) enzymes degrade cGMP into 5’GMP and therefore they are involved in the regulation of intracellular levels of cGMP. Here we review a growing body of evidence suggesting that the cGMP signaling cascade warrants further investigation for its involvement in MDD and antidepressant action.
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spelling pubmed-32634652012-06-01 cGMP Signaling, Phosphodiesterases and Major Depressive Disorder Reierson, Gillian W Guo, Shuyu Mastronardi, Claudio Licinio, Julio Wong, Ma-Li Curr Neuropharmacol Article Deficits in neuroplasticity are hypothesized to underlie the pathophysiology of major depressive disorder (MDD): the effectiveness of antidepressants is thought to be related to the normalization of disrupted synaptic transmission and neurogenesis. The cyclic adenosine monophosphate (cAMP) signaling cascade has received considerable attention for its role in neuroplasticity and MDD. However components of a closely related pathway, the cyclic guanosine monophosphate (cGMP) have been studied with much lower intensity, even though this signaling transduction cascade is also expressed in the brain and the activity of this pathway has been implicated in learning and memory processes. Cyclic GMP acts as a second messenger; it amplifies signals received at postsynaptic receptors and activates downstream effector molecules resulting in gene expression changes and neuronal responses. Phosphodiesterase (PDE) enzymes degrade cGMP into 5’GMP and therefore they are involved in the regulation of intracellular levels of cGMP. Here we review a growing body of evidence suggesting that the cGMP signaling cascade warrants further investigation for its involvement in MDD and antidepressant action. Bentham Science Publishers 2011-12 /pmc/articles/PMC3263465/ /pubmed/22654729 http://dx.doi.org/10.2174/157015911798376271 Text en ©2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Reierson, Gillian W
Guo, Shuyu
Mastronardi, Claudio
Licinio, Julio
Wong, Ma-Li
cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
title cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
title_full cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
title_fullStr cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
title_full_unstemmed cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
title_short cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
title_sort cgmp signaling, phosphodiesterases and major depressive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263465/
https://www.ncbi.nlm.nih.gov/pubmed/22654729
http://dx.doi.org/10.2174/157015911798376271
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