Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology

The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 3(2) full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X (1)) and stirring speed (X (2)), on dependent variables, en...

Descripción completa

Detalles Bibliográficos
Autores principales: Dey, Sanjay, Pramanik, Soumen, Malgope, Ananya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263718/
https://www.ncbi.nlm.nih.gov/pubmed/22389855
http://dx.doi.org/10.5402/2011/627623
_version_ 1782221917949788160
author Dey, Sanjay
Pramanik, Soumen
Malgope, Ananya
author_facet Dey, Sanjay
Pramanik, Soumen
Malgope, Ananya
author_sort Dey, Sanjay
collection PubMed
description The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 3(2) full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X (1)) and stirring speed (X (2)), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release.
format Online
Article
Text
id pubmed-3263718
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher International Scholarly Research Network
record_format MEDLINE/PubMed
spelling pubmed-32637182012-03-02 Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology Dey, Sanjay Pramanik, Soumen Malgope, Ananya ISRN Pharm Research Article The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 3(2) full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X (1)) and stirring speed (X (2)), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release. International Scholarly Research Network 2011 2011-06-28 /pmc/articles/PMC3263718/ /pubmed/22389855 http://dx.doi.org/10.5402/2011/627623 Text en Copyright © 2011 Sanjay Dey et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dey, Sanjay
Pramanik, Soumen
Malgope, Ananya
Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
title Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
title_full Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
title_fullStr Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
title_full_unstemmed Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
title_short Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
title_sort formulation and optimization of sustained release stavudine microspheres using response surface methodology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263718/
https://www.ncbi.nlm.nih.gov/pubmed/22389855
http://dx.doi.org/10.5402/2011/627623
work_keys_str_mv AT deysanjay formulationandoptimizationofsustainedreleasestavudinemicrospheresusingresponsesurfacemethodology
AT pramaniksoumen formulationandoptimizationofsustainedreleasestavudinemicrospheresusingresponsesurfacemethodology
AT malgopeananya formulationandoptimizationofsustainedreleasestavudinemicrospheresusingresponsesurfacemethodology

Ejemplares similares