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An autoimmune disease prevented by anti-retroviral drugs
BACKGROUND: Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and the autoimmune disease systemic lupus erythematosus can result from mutations in the gene encoding the enzyme Trex1. In mice, the absence of Trex1 causes severe myocarditis. The enzyme is thought to degrade e...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264515/ https://www.ncbi.nlm.nih.gov/pubmed/22067273 http://dx.doi.org/10.1186/1742-4690-8-91 |