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Forebrain Deletion of αGDI in Adult Mice Worsens the Pre-Synaptic Deficit at Cortico-Lateral Amygdala Synaptic Connections

The GDI1 gene encodes αGDI, which retrieves inactive GDP-bound RAB from membranes to form a cytosolic pool awaiting vesicular release. Mutations in GDI1 are responsible for X-linked Intellectual Disability. Characterization of the Gdi1-null mice has revealed alterations in the total number and distr...

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Detalles Bibliográficos
Autores principales: Bianchi, Veronica, Gambino, Frédéric, Muzio, Luca, Toniolo, Daniela, Humeau, Yann, D'Adamo, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264564/
https://www.ncbi.nlm.nih.gov/pubmed/22291894
http://dx.doi.org/10.1371/journal.pone.0029763