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Effects of Ligands on Unfolding of the Amyloid β-Peptide Central Helix: Mechanistic Insights from Molecular Dynamics Simulations

Polymerization of the amyloid β-peptide (Aβ), a process which requires that the helical structure of Aβ unfolds beforehand, is suspected to cause neurodegeneration in Alzheimer's disease. According to recent experimental studies, stabilization of the Aβ central helix counteracts Aβ polymerizati...

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Detalles Bibliográficos
Autores principales: Ito, Mika, Johansson, Jan, Strömberg, Roger, Nilsson, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264620/
https://www.ncbi.nlm.nih.gov/pubmed/22291970
http://dx.doi.org/10.1371/journal.pone.0030510