Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways

SNCA and MAPT genes and environmental factors are important risk factors of Parkinson's disease [PD], the second-most common neurodegenerative disease. The agrichemicals maneb and paraquat selectively target dopaminergic neurons, leading to parkinsonism, through ill-defined mechanisms. In the c...

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Detalles Bibliográficos
Autores principales: Wills, Jonathan, Credle, Joel, Oaks, Adam W., Duka, Valeriy, Lee, Jae-Hoon, Jones, Jessica, Sidhu, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264632/
https://www.ncbi.nlm.nih.gov/pubmed/22292029
http://dx.doi.org/10.1371/journal.pone.0030745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264632/
https://www.ncbi.nlm.nih.gov/pubmed/22292029
http://dx.doi.org/10.1371/journal.pone.0030745

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