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The Accessibility in the External Part of the TM5 of the Glutamate Transporter EAAT1 Is Conformationally Sensitive during the Transport Cycle

BACKGROUND: Excitatory amino acid transporter 1 (EAAT1) is a glutamate transporter which is a key element in the termination of the synaptic actions of glutamate. It serves to keep the extracellular glutamate concentration below neurotoxic level. However the functional significance and the change of...

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Detalles Bibliográficos
Autores principales: Zhang, Xiuping, Qu, Shaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264643/
https://www.ncbi.nlm.nih.gov/pubmed/22292083
http://dx.doi.org/10.1371/journal.pone.0030961