Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions

[Image: see text] A current hypothesis for the pathology of Alzheimer’s disease (AD) proposes that amyloid-β (Aβ) peptides induce uncontrolled, neurotoxic ion flux across cellular membranes. The mechanism of ion flux is not fully understood because no experiment-based Aβ channel structures at atomic...

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Detalles Bibliográficos
Autores principales: Capone, Ricardo, Jang, Hyunbum, Kotler, Samuel A., Kagan, Bruce L., Nussinov, Ruth, Lal, Ratnesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265145/
https://www.ncbi.nlm.nih.gov/pubmed/22242635
http://dx.doi.org/10.1021/bi2017427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265145/
https://www.ncbi.nlm.nih.gov/pubmed/22242635
http://dx.doi.org/10.1021/bi2017427

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