Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor–2α

PURPOSE: Hypoxia is a critical pathological factor in a variety of retinal diseases, including age-related macular degeneration. It upregulates angiogenic growth factors and promotes neovascularization. Hypoxia changes the cellular redox state and activates class III histone deacetylase sirtuin1 (SI...

Descripción completa

Detalles Bibliográficos
Autores principales: Balaiya, Sankarathi, Khetpal, Vijay, Chalam, Kakarla V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265172/
https://www.ncbi.nlm.nih.gov/pubmed/22275802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265172/
https://www.ncbi.nlm.nih.gov/pubmed/22275802

Ejemplares similares