The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor

The major obstacle in platinum chemotherapy is the repair of platinum-damaged DNA that results in increased resistance, reduced apoptosis, and finally treatment failure. Our research goal is to determine and block the mechanisms of platinum resistance. Our recent studies demonstrate that several kin...

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Detalles Bibliográficos
Autores principales: Liang, Xiaobing, Guo, Yi, Figg, William Douglas, Fojo, Antonio Tito, Mueller, Michael D., Yu, Jing Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265242/
https://www.ncbi.nlm.nih.gov/pubmed/22312557
http://dx.doi.org/10.1155/2011/715469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265242/
https://www.ncbi.nlm.nih.gov/pubmed/22312557
http://dx.doi.org/10.1155/2011/715469

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