Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

In addition to endocytosis-mediated cellular uptake, hydrophilic cell-penetrating peptides are able to traverse biological membranes in a non-endocytic mode termed transduction, resulting in immediate bioavailability. Here we analysed structural requirements for the non-endocytic uptake mode of argi...

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Detalles Bibliográficos
Autores principales: Lättig-Tünnemann, Gisela, Prinz, Manuel, Hoffmann, Daniel, Behlke, Joachim, Palm-Apergi, Caroline, Morano, Ingo, Herce, Henry D., Cardoso, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265364/
https://www.ncbi.nlm.nih.gov/pubmed/21878907
http://dx.doi.org/10.1038/ncomms1459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265364/
https://www.ncbi.nlm.nih.gov/pubmed/21878907
http://dx.doi.org/10.1038/ncomms1459

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