Functional Characterization of MODY2 Mutations Highlights the Importance of the Fine-Tuning of Glucokinase and Its Role in Glucose Sensing

Glucokinase (GK) acts as a glucose sensor in the pancreatic beta-cell and regulates insulin secretion. Heterozygous mutations in the human GK-encoding GCK gene that reduce the activity index increase the glucose-stimulated insulin secretion threshold and cause familial, mild fasting hyperglycaemia,...

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Detalles Bibliográficos
Autores principales: García-Herrero, Carmen-María, Rubio-Cabezas, Oscar, Azriel, Sharona, Gutierrez-Nogués, Angel, Aragonés, Angel, Vincent, Olivier, Campos-Barros, Angel, Argente, Jesús, Navas, María-Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265476/
https://www.ncbi.nlm.nih.gov/pubmed/22291974
http://dx.doi.org/10.1371/journal.pone.0030518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265476/
https://www.ncbi.nlm.nih.gov/pubmed/22291974
http://dx.doi.org/10.1371/journal.pone.0030518

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