Lentiviral Transgenic MicroRNA-Based shRNA Suppressed Mouse Cytochromosome P450 3A (CYP3A) Expression in a Dose-Dependent and Inheritable Manner

Cytochomosome P450 enzymes (CYP) are heme-containing monooxygenases responsible for oxidative metabolism of many exogenous and endogenous compounds including drugs. The species difference of CYP limits the extent to which data obtained from animals can be translated to humans in pharmacodynamics or...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yong, Hu, Hai-Hong, Pang, Hao, Zhou, Xiao-Yang, Yu, Lu-Shan, Wang, Lu-Lu, Liu, Cang'e, Guo, Ke-Nan, Zhao, Cong, Liu, Qin, Zeng, Ben-Hua, Tang, Huan, Shang, Hai-Tao, Zeng, Su, Wei, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265487/
https://www.ncbi.nlm.nih.gov/pubmed/22291988
http://dx.doi.org/10.1371/journal.pone.0030560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265487/
https://www.ncbi.nlm.nih.gov/pubmed/22291988
http://dx.doi.org/10.1371/journal.pone.0030560

Ejemplares similares