Cargando…

Lentiviral Transgenic MicroRNA-Based shRNA Suppressed Mouse Cytochromosome P450 3A (CYP3A) Expression in a Dose-Dependent and Inheritable Manner

Cytochomosome P450 enzymes (CYP) are heme-containing monooxygenases responsible for oxidative metabolism of many exogenous and endogenous compounds including drugs. The species difference of CYP limits the extent to which data obtained from animals can be translated to humans in pharmacodynamics or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yong, Hu, Hai-Hong, Pang, Hao, Zhou, Xiao-Yang, Yu, Lu-Shan, Wang, Lu-Lu, Liu, Cang'e, Guo, Ke-Nan, Zhao, Cong, Liu, Qin, Zeng, Ben-Hua, Tang, Huan, Shang, Hai-Tao, Zeng, Su, Wei, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265487/ https://www.ncbi.nlm.nih.gov/pubmed/22291988 http://dx.doi.org/10.1371/journal.pone.0030560

Ejemplares similares

Construction of shRNA lentiviral vector
por: Song, Hong, et al.
Publicado: (2010)

Downregulation of mouse CCR3 by lentiviral shRNA inhibits proliferation and induces apoptosis of mouse eosinophils
por: Zhu, Xin-Hua, et al.
Publicado: (2017)

Energy profile and secondary structure impact shRNA efficacy
por: Zhou, Hong, et al.
Publicado: (2009)

Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition
por: Brake, Olivier ter, et al.
Publicado: (2008)

Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer
por: Anastasov, Nataša, et al.
Publicado: (2008)

Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success
por: Mcintyre, Glen J, et al.
Publicado: (2009)

Construction and verification of the targeted uPA-shRNA lentiviral vector and evaluation of the transfection and silencing rate
por: WANG, WEI-SHAN, et al.
Publicado: (2014)

Lentiviral shRNA against KCa3.1 inhibits allergic response in allergic rhinitis and suppresses mast cell activity via PI3K/AKT signaling pathway
por: Lin, Hai, et al.
Publicado: (2015)

Optimized PCR Conditions and Increased shRNA Fold Representation Improve Reproducibility of Pooled shRNA Screens
por: Strezoska, Žaklina, et al.
Publicado: (2012)

ShRNA-Targeted COMMD7 Suppresses Hepatocellular Carcinoma Growth
por: Zheng, Lu, et al.
Publicado: (2012)

Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells
por: Witkowski, Wojciech, et al.
Publicado: (2015)

A descriptive guide for absolute quantification of produced shRNA pseudotyped lentiviral particles by real-time PCR
por: Mournetas, Virginie, et al.
Publicado: (2016)

In Vivo Suppression of Autophagy via Lentiviral shRNA Targeting Atg5 Improves Lupus-Like Syndrome
por: Liu, Chi-Jui, et al.
Publicado: (2020)

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation
por: Rau, Andrea, et al.
Publicado: (2022)

A Comparison of Target Gene Silencing using Synthetically Modified siRNA and shRNA That Express Recombinant Lentiviral Vectors
por: Spirin, P.V., et al.
Publicado: (2009)

Correction: ShRNA-Targeted COMMD7 Suppresses Hepatocellular Carcinoma Growth
por: Zheng, Lu, et al.
Publicado: (2019)

A Method to Assess Target Gene Involvement in Angiogenesis In Vitro and In Vivo Using Lentiviral Vectors Expressing shRNA
por: Blosser, Wayne, et al.
Publicado: (2014)

Construction of a lentiviral vector containing shRNA targeting ADAM17 and its role in attenuating endotoxemia in mice
por: He, Bing, et al.
Publicado: (2017)

Construction of a lentiviral vector containing shRNA targeting ADAM17 and its role in attenuating endotoxemia in mice
por: He, Bing, et al.
Publicado: (2018)

Corrigendum: A descriptive guide for absolute quantification of produced shRNA pseudotyped lentiviral particles by real-time PCR
por: Mournetas, Virginie, et al.
Publicado: (2019)

Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression
por: Xu, Siyun, et al.
Publicado: (2014)

Optimization and characterization of tRNA-shRNA expression constructs
por: Scherer, Lisa J., et al.
Publicado: (2007)

Improved siRNA/shRNA Functionality by Mismatched Duplex
por: Wu, Haoquan, et al.
Publicado: (2011)

shRNA target prediction informed by comprehensive enquiry (SPICE): a supporting system for high-throughput screening of shRNA library
por: Kamatuka, Kenta, et al.
Publicado: (2016)

Lentiviral delivery of CTLA-4 shRNA improves the expansion of cytokine-induced killer cells and enhances cytotoxic activity in vitro
por: Rui, Tao, et al.
Publicado: (2018)

A novel treatment approach for retinoblastoma by targeting epithelial growth factor receptor expression with a shRNA lentiviral system
por: Chai, Yong, et al.
Publicado: (2017)

Suppression of IL-6 Gene by shRNA Augments Gemcitabine Chemosensitization in Pancreatic Adenocarcinoma Cells
por: Xing, Hai-Bo, et al.
Publicado: (2018)

A Simple and Robust Vector-Based shRNA Expression System Used for RNA Interference
por: Wang, Xue-jun, et al.
Publicado: (2013)

Lentiviral vector‐encoded microRNA‐based shRNA‐mediated gene knockdown of N‐methyl‐D‐aspartate receptors in skin reduces pain
por: Liu, Chien‐Cheng, et al.
Publicado: (2016)

Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates
por: Ajiro, Masahiko, et al.
Publicado: (2015)

Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion
por: Huang, XiaoDong, et al.
Publicado: (2008)

Corrigendum to “Suppression of IL-6 Gene by shRNA Augments Gemcitabine Chemosensitization in Pancreatic Adenocarcinoma Cells”
por: Xing, Hai-Bo, et al.
Publicado: (2022)

A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency
por: He, Jiening, et al.
Publicado: (2015)

Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors
por: Zorzan, Maira, et al.
Publicado: (2021)

Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β(0)-thalassemia/HbE erythroid cells
por: Chumchuen, Sukanya, et al.
Publicado: (2023)

Design and cloning strategies for constructing shRNA expression vectors
por: McIntyre, Glen J, et al.
Publicado: (2006)

The effects of stem length and core placement on shRNA activity
por: Mcintyre, Glen J, et al.
Publicado: (2011)

Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
por: Matveeva, Olga V., et al.
Publicado: (2010)

Production of Transgenic Calves Expressing an shRNA Targeting Myostatin
por: Tessanne, K, et al.
Publicado: (2012)

Suppression of Cancer Progression by MGAT1 shRNA Knockdown
por: Beheshti Zavareh, Reza, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tpqhcdq7tdmuomdj8m4gr4i4o7