Tuning Protein Autoinhibition by Domain Destabilization

Activation of many multi-domain signaling proteins requires rearrangement of autoinhibitory interdomain interactions that occlude activator binding sites. In one model for activation, the major inactive conformation exists in equilibrium with activated-like conformations that can be stabilized by li...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Jae-Hyun, Muralidharan, Vasant, Vila-Perello, Miquel, Raleigh, Daniel P., Muir, Tom W., Palmer, Arthur G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265570/
https://www.ncbi.nlm.nih.gov/pubmed/21532593
http://dx.doi.org/10.1038/nsmb.2039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265570/
https://www.ncbi.nlm.nih.gov/pubmed/21532593
http://dx.doi.org/10.1038/nsmb.2039

Ejemplares similares