A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression

Mutation of the tumor suppressor adenomatous polyposis coli (APC) is considered an initiating step in the genesis of the vast majority of colorectal cancers. APC inhibits the Wnt signaling pathway by targeting proto-oncogene β-catenin for destruction by cytoplasmic proteasomes. In the presence of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeineldin, Maged, Cunningham, Jamie, McGuinness, William, Alltizer, Preston, Cowley, Brett, Blanchat, Bryan, Xu, Wenhao, Pinson, David, Neufeld, Kristi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265630/
https://www.ncbi.nlm.nih.gov/pubmed/21996741
http://dx.doi.org/10.1038/onc.2011.434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265630/
https://www.ncbi.nlm.nih.gov/pubmed/21996741
http://dx.doi.org/10.1038/onc.2011.434

Ejemplares similares