Cargando…

A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression

Mutation of the tumor suppressor adenomatous polyposis coli (APC) is considered an initiating step in the genesis of the vast majority of colorectal cancers. APC inhibits the Wnt signaling pathway by targeting proto-oncogene β-catenin for destruction by cytoplasmic proteasomes. In the presence of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeineldin, Maged, Cunningham, Jamie, McGuinness, William, Alltizer, Preston, Cowley, Brett, Blanchat, Bryan, Xu, Wenhao, Pinson, David, Neufeld, Kristi L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265630/ https://www.ncbi.nlm.nih.gov/pubmed/21996741 http://dx.doi.org/10.1038/onc.2011.434

Ejemplares similares

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

Novel association of APC with intermediate filaments identified using a new versatile APC antibody
por: Wang, Yang, et al.
Publicado: (2009)

Wnt signaling and colon carcinogenesis: Beyond APC
por: Najdi, Rani, et al.
Publicado: (2011)

APC Moonlights to Prevent Wnt Signalosome Assembly
por: McGough, Ian John, et al.
Publicado: (2018)

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response
por: Stefanski, Casey D., et al.
Publicado: (2020)

Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors
por: Al-Thani, Nayra M., et al.
Publicado: (2022)

Protoparvovirus Knocking at the Nuclear Door
por: Mäntylä, Elina, et al.
Publicado: (2017)

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
por: Tacchelly-Benites, Ofelia, et al.
Publicado: (2018)

APC sets the Wnt tone necessary for cerebral cortical progenitor development
por: Nakagawa, Naoki, et al.
Publicado: (2017)

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
por: Lee, Ethan, et al.
Publicado: (2003)

Thymoquinone attenuates tumor growth in Apc(Min) mice by interference with Wnt-signaling
por: Lang, Michaela, et al.
Publicado: (2013)

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression
por: Mohamed, Noha-Ehssan, et al.
Publicado: (2019)

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer
por: Kang, Hee Eun, et al.
Publicado: (2021)

SATB2 loss in inflammatory bowel disease-associated small intestinal metaplasia of the distal colon
por: Zeineldin, Maged, et al.
Publicado: (2023)

Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts
por: Cai, Yumei, et al.
Publicado: (2018)

Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions
por: Benary, Uwe, et al.
Publicado: (2013)

Identification and optimisation of next generation inhibitors of IDO1 and TDO
por: Wise, Alan, et al.
Publicado: (2015)

Tissue-Dependent Consequences of Apc Inactivation on Proliferation and Differentiation of Ciliated Cell Progenitors via Wnt and Notch Signaling
por: Li, Aimin, et al.
Publicado: (2013)

Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Publicado: (2004)

Dementia
por: Cunningham, EL, et al.
Publicado: (2015)

Fundamentals of electronic resources management
por: Verminski, Alana, et al.
Publicado: (2017)

Correction: Tissue-Dependent Consequences of Apc Inactivation on Proliferation and Differentiation of Ciliated Cell Progenitors via Wnt and Notch Signaling
por: Li, Aimin, et al.
Publicado: (2013)

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
por: Roberts, David M., et al.
Publicado: (2011)

Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1
por: Hankey, William, et al.
Publicado: (2018)

Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway
por: Li, Fei-Feng, et al.
Publicado: (2017)

Cytoskeletal Control and Wnt Signaling—APC’s Dual Contributions in Stem Cell Division and Colorectal Cancer
por: Juanes, M. Angeles
Publicado: (2020)

Quasielastic knock-out of clusters by electrons and nuclear restructuring effects
por: Sakharuk, A, et al.
Publicado: (1999)

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain
por: Cronin, Nora B., et al.
Publicado: (2015)

Wittgenstein : el joven Ludwig (1889-1921)
por: McGuinness, Brian
Publicado: (1991)

Becoming confident teachers: a guide for academic librarians
por: McGuinness, Claire
Publicado: (2011)

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex
por: Kunttas-Tatli, Ezgi, et al.
Publicado: (2014)

α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
por: Choi, Seung H., et al.
Publicado: (2013)

The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling
por: Chen, Xi, et al.
Publicado: (2023)

Exercise through Shaking Stimuli Suppresses Cancer Growth via the Wnt pathway in Apc(Min/+) Mice
por: Iwata, Daiki, et al.
Publicado: (2023)

The importance of APC
por: Ablamunits, Vitaly
Publicado: (2005)

Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint
por: Wild, Thomas, et al.
Publicado: (2018)

Subtle Deregulation of the Wnt‐Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells
por: Young, Madeleine A., et al.
Publicado: (2017)

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination
por: Wu, Xiao-Ting, et al.
Publicado: (2021)

Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC
por: Faux, Maree C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fl6q5m4s85hqn052hbvcncn000