Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

Two multicentre genome-wide association (GWA) studies provided substantial evidence, implicating the complement receptor 1 gene (CR1) in Alzheimer disease (AD) genetic etiology. CR1 encodes a large transmembrane receptor with a crucial role in the immune complement cascade. We performed a genetic fo...

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Detalles Bibliográficos
Autores principales: Brouwers, N, Van Cauwenberghe, C, Engelborghs, S, Lambert, J-C, Bettens, K, Le Bastard, N, Pasquier, F, Montoya, A Gil, Peeters, K, Mattheijssens, M, Vandenberghe, R, De Deyn, P P, Cruts, M, Amouyel, P, Sleegers, K, Van Broeckhoven, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265835/
https://www.ncbi.nlm.nih.gov/pubmed/21403675
http://dx.doi.org/10.1038/mp.2011.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265835/
https://www.ncbi.nlm.nih.gov/pubmed/21403675
http://dx.doi.org/10.1038/mp.2011.24

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