PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain

BACKGROUND: Chronic pain occurs when normally protective acute pain becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-term memory storage in various brain regions, also sustains nociceptive plasticity in spinal cord dorsal hor...

Descripción completa

Detalles Bibliográficos
Autores principales: Laferrière, Andre, Pitcher, Mark H, Haldane, Anne, Huang, Yue, Cornea, Virginia, Kumar, Naresh, Sacktor, Todd C, Cervero, Fernando, Coderre, Terence J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266216/
https://www.ncbi.nlm.nih.gov/pubmed/22185613
http://dx.doi.org/10.1186/1744-8069-7-99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266216/
https://www.ncbi.nlm.nih.gov/pubmed/22185613
http://dx.doi.org/10.1186/1744-8069-7-99

Ejemplares similares