ELR510444 Inhibits Tumor Growth and Angiogenesis by Abrogating HIF Activity and Disrupting Microtubules in Renal Cell Carcinoma

BACKGROUND: Hypoxia-inducible factor (HIF) is an attractive therapeutic target for renal cell carcinoma (RCC) as its high expression due to the loss of von Hippel-Lindau (VHL) promotes RCC progression. Considering this, we hypothesized that ELR510444, a novel orally available small molecule inhibito...

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Detalles Bibliográficos
Autores principales: Carew, Jennifer S., Esquivel, Juan A., Espitia, Claudia M., Schultes, Christoph M., Mülbaier, Marcel, Lewis, Joe D., Janssen, Bernd, Giles, Francis J., Nawrocki, Steffan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266297/
https://www.ncbi.nlm.nih.gov/pubmed/22295124
http://dx.doi.org/10.1371/journal.pone.0031120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266297/
https://www.ncbi.nlm.nih.gov/pubmed/22295124
http://dx.doi.org/10.1371/journal.pone.0031120

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