Regulated and Reversible Induction of Adult Human β-Cell Replication

Induction of proliferation in adult human β-cells is challenging. It can be accomplished by introduction of cell cycle molecules such as cyclin-dependent kinase 6 (cdk6) and cyclin D(1), but their continuous overexpression raises oncogenic concerns. We attempted to mimic normal, transient, perinatal...

Descripción completa

Detalles Bibliográficos
Autores principales: Takane, Karen K., Kleinberger, Jeffery W., Salim, Fatimah G., Fiaschi-Taesch, Nathalie M., Stewart, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266420/
https://www.ncbi.nlm.nih.gov/pubmed/22210317
http://dx.doi.org/10.2337/db11-0580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266420/
https://www.ncbi.nlm.nih.gov/pubmed/22210317
http://dx.doi.org/10.2337/db11-0580

Ejemplares similares