A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

Auranofin is a gold(I)-containing drug in clinical use as an antiarthritic agent. Recent studies showed that auranofin manifests interesting antiparasitic actions very likely arising from inhibition of parasitic enzymes involved in the control of the redox metabolism. Trypanothione reductase is a ke...

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Detalles Bibliográficos
Autores principales: Ilari, Andrea, Baiocco, Paola, Messori, Luigi, Fiorillo, Annarita, Boffi, Alberto, Gramiccia, Marina, Di Muccio, Trentina, Colotti, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266496/
https://www.ncbi.nlm.nih.gov/pubmed/21833767
http://dx.doi.org/10.1007/s00726-011-0997-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266496/
https://www.ncbi.nlm.nih.gov/pubmed/21833767
http://dx.doi.org/10.1007/s00726-011-0997-9

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