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Toward a New Gold Standard for Early Safety: Automated Temperature-Controlled hERG Test on the PatchLiner(®)
The Patchliner® temperature-controlled automated patch clamp system was evaluated for testing drug effects on potassium currents through human ether-à-go-go related gene (hERG) channels expressed in Chinese hamster ovary cells at 35–37°C. IC(50) values for a set of reference drugs were compared with...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266667/ https://www.ncbi.nlm.nih.gov/pubmed/22303293 http://dx.doi.org/10.3389/fphar.2012.00003 |