Cargando…
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic de...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266853/ https://www.ncbi.nlm.nih.gov/pubmed/22281744 http://dx.doi.org/10.1107/S0907444911053042 |
_version_ | 1782222212016635904 |
---|---|
author | Klejnot, Marta Kozielski, Frank |
author_facet | Klejnot, Marta Kozielski, Frank |
author_sort | Klejnot, Marta |
collection | PubMed |
description | Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melanogaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance. |
format | Online Article Text |
id | pubmed-3266853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32668532012-01-30 Structural insights into human Kif7, a kinesin involved in Hedgehog signalling Klejnot, Marta Kozielski, Frank Acta Crystallogr D Biol Crystallogr Research Papers Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melanogaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance. International Union of Crystallography 2012-02-01 2012-01-13 /pmc/articles/PMC3266853/ /pubmed/22281744 http://dx.doi.org/10.1107/S0907444911053042 Text en © Klejnot & Kozielski 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Research Papers Klejnot, Marta Kozielski, Frank Structural insights into human Kif7, a kinesin involved in Hedgehog signalling |
title | Structural insights into human Kif7, a kinesin involved in Hedgehog signalling |
title_full | Structural insights into human Kif7, a kinesin involved in Hedgehog signalling |
title_fullStr | Structural insights into human Kif7, a kinesin involved in Hedgehog signalling |
title_full_unstemmed | Structural insights into human Kif7, a kinesin involved in Hedgehog signalling |
title_short | Structural insights into human Kif7, a kinesin involved in Hedgehog signalling |
title_sort | structural insights into human kif7, a kinesin involved in hedgehog signalling |
topic | Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266853/ https://www.ncbi.nlm.nih.gov/pubmed/22281744 http://dx.doi.org/10.1107/S0907444911053042 |
work_keys_str_mv | AT klejnotmarta structuralinsightsintohumankif7akinesininvolvedinhedgehogsignalling AT kozielskifrank structuralinsightsintohumankif7akinesininvolvedinhedgehogsignalling |