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Structural insights into human Kif7, a kinesin involved in Hedgehog signalling

Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic de...

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Autores principales: Klejnot, Marta, Kozielski, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266853/
https://www.ncbi.nlm.nih.gov/pubmed/22281744
http://dx.doi.org/10.1107/S0907444911053042
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author Klejnot, Marta
Kozielski, Frank
author_facet Klejnot, Marta
Kozielski, Frank
author_sort Klejnot, Marta
collection PubMed
description Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melano­gaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance.
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spelling pubmed-32668532012-01-30 Structural insights into human Kif7, a kinesin involved in Hedgehog signalling Klejnot, Marta Kozielski, Frank Acta Crystallogr D Biol Crystallogr Research Papers Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melano­gaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance. International Union of Crystallography 2012-02-01 2012-01-13 /pmc/articles/PMC3266853/ /pubmed/22281744 http://dx.doi.org/10.1107/S0907444911053042 Text en © Klejnot & Kozielski 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Papers
Klejnot, Marta
Kozielski, Frank
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
title Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
title_full Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
title_fullStr Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
title_full_unstemmed Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
title_short Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
title_sort structural insights into human kif7, a kinesin involved in hedgehog signalling
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266853/
https://www.ncbi.nlm.nih.gov/pubmed/22281744
http://dx.doi.org/10.1107/S0907444911053042
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