Cargando…
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic de...
Autores principales: | Klejnot, Marta, Kozielski, Frank |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266853/ https://www.ncbi.nlm.nih.gov/pubmed/22281744 http://dx.doi.org/10.1107/S0907444911053042 |
Ejemplares similares
-
The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development
por: Klejnot, Marta, et al.
Publicado: (2013) -
The Kinesin-4 Protein KIF7 Regulates Mammalian Hedgehog Signaling by Organizing the Cilia Tip Compartment
por: He, Mu, et al.
Publicado: (2014) -
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding
por: Yue, Yang, et al.
Publicado: (2022) -
Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7
por: Yue, Yang, et al.
Publicado: (2018) -
Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
por: Wang, Weiyi, et al.
Publicado: (2017)