F box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest

Dyregulated behavior of cell cycle proteins and their control by ubiquitin E3 ligases is an emerging theme in human lung cancer. Here we identified and characterized the activity of a novel F box protein, termed FBXL2, belonging to the SCF (Skip-Cullin1-F-box protein) E3 ligase family. Ectopically e...

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Detalles Bibliográficos
Autores principales: Chen, Bill B., Glasser, Jennifer R., Coon, Tiffany A., Mallampalli, Rama K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266958/
https://www.ncbi.nlm.nih.gov/pubmed/22020328
http://dx.doi.org/10.1038/onc.2011.432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266958/
https://www.ncbi.nlm.nih.gov/pubmed/22020328
http://dx.doi.org/10.1038/onc.2011.432

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