Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

BACKGROUND: HIV-1 infects non-dividing cells. This implies that the virus traverses the nuclear pore before it integrates into chromosomal DNA. Recent studies demonstrated that TNPO3 is required for full infectivity of HIV-1. The fact that TNPO3 is a karyopherin suggests that it acts by directly pro...

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Detalles Bibliográficos
Autores principales: De Iaco, Alberto, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267670/
https://www.ncbi.nlm.nih.gov/pubmed/22145813
http://dx.doi.org/10.1186/1742-4690-8-98

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267670/
https://www.ncbi.nlm.nih.gov/pubmed/22145813
http://dx.doi.org/10.1186/1742-4690-8-98

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