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Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes

Human CD4(+) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound self-peptides presented by CD4(+) T cells in order to compare the T cell-der...

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Detalles Bibliográficos
Autores principales: Costantino, Cristina Maria, Spooner, Eric, Ploegh, Hidde L., Hafler, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267721/
https://www.ncbi.nlm.nih.gov/pubmed/22299025
http://dx.doi.org/10.1371/journal.pone.0029805