LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

Leucine-rich repeat kinase 2 (LRRK2), a large protein kinase containing multi-functional domains, has been identified as the causal molecule for autosomal-dominant Parkinson's disease (PD). In the present study, we demonstrated for the first time that (i) LRRK2 interacts with tau in a tubulin-d...

Descripción completa

Detalles Bibliográficos
Autores principales: Kawakami, Fumitaka, Yabata, Takatoshi, Ohta, Etsuro, Maekawa, Tatsunori, Shimada, Naoki, Suzuki, Minori, Maruyama, Hiroko, Ichikawa, Takafumi, Obata, Fumiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267742/
https://www.ncbi.nlm.nih.gov/pubmed/22303461
http://dx.doi.org/10.1371/journal.pone.0030834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267742/
https://www.ncbi.nlm.nih.gov/pubmed/22303461
http://dx.doi.org/10.1371/journal.pone.0030834

Ejemplares similares