Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Genomic duplications spanning Xq28 are associated with a spectrum of phenotypes including anxiety and autism. The minimal region shared among affected individuals includes MECP2 and IRAK1, however, it is unclear which gene, when overexpressed, causes anxiety and social behavior deficits. We report t...

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Detalles Bibliográficos
Autores principales: Samaco, Rodney C, Mandel-Brehm, Caleigh, McGraw, Christopher M, Shaw, Chad A, McGill, Bryan E, Zoghbi, Huda Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267865/
https://www.ncbi.nlm.nih.gov/pubmed/22231481
http://dx.doi.org/10.1038/ng.1066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267865/
https://www.ncbi.nlm.nih.gov/pubmed/22231481
http://dx.doi.org/10.1038/ng.1066

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