Cargando…

Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Genomic duplications spanning Xq28 are associated with a spectrum of phenotypes including anxiety and autism. The minimal region shared among affected individuals includes MECP2 and IRAK1, however, it is unclear which gene, when overexpressed, causes anxiety and social behavior deficits. We report t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Samaco, Rodney C, Mandel-Brehm, Caleigh, McGraw, Christopher M, Shaw, Chad A, McGill, Bryan E, Zoghbi, Huda Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267865/ https://www.ncbi.nlm.nih.gov/pubmed/22231481 http://dx.doi.org/10.1038/ng.1066

Ejemplares similares

Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia
por: Ward, Christopher S., et al.
Publicado: (2020)

Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
por: Heckman, Laura Dean, et al.
Publicado: (2014)

Genetic rodent models of brain disorders: Perspectives on experimental approaches and therapeutic strategies
por: McGraw, Christopher M., et al.
Publicado: (2017)

Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome
por: Ash, Ryan T., et al.
Publicado: (2018)

Excessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2-Duplication Syndrome Mouse Model of Autism
por: Ash, Ryan Thomas, et al.
Publicado: (2021)

Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus
por: Ben-Shachar, Shay, et al.
Publicado: (2009)

Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligos
por: Sztainberg, Yehezkel, et al.
Publicado: (2015)

Medical Comorbidities in MECP2 Duplication Syndrome: Results from the International MECP2 Duplication Database
por: Ta, Daniel, et al.
Publicado: (2022)

Duplication within two regions distal to MECP2: clinical similarity with MECP2 duplication syndrome
por: Akahoshi, Keiko, et al.
Publicado: (2023)

Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome
por: Veeraragavan, Surabi, et al.
Publicado: (2016)

Rett Syndrome and MECP2 Duplication Syndrome: Disorders of MeCP2 Dosage
por: Collins, Bridget E, et al.
Publicado: (2022)

Genetic Modifiers of MeCP2 Function in Drosophila
por: Cukier, Holly N., et al.
Publicado: (2008)

MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions
por: Sun, Na, et al.
Publicado: (2021)

Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism
por: Ash, Ryan Thomas, et al.
Publicado: (2021)

MECP2 duplication syndrome in a Chinese family
por: Zhang, Qingping, et al.
Publicado: (2015)

Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome
por: Bauer, Michael, et al.
Publicado: (2015)

Cortisol profiles and clinical severity in MECP2 duplication syndrome
por: Peters, Sarika U., et al.
Publicado: (2020)

A partial MECP2 duplication in a mildly affected adult male: a putative role for the 3' untranslated region in the MECP2 duplication phenotype
por: Hanchard, Neil A, et al.
Publicado: (2012)

Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP
por: Enoch, Mary-Anne, et al.
Publicado: (2008)

Aberrant brain functional and structural developments in MECP2 duplication rats
por: Xu, Ming, et al.
Publicado: (2022)

Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions
por: Shao, Yingyao, et al.
Publicado: (2021)

The Development and Validation of a Revised Version of the Math Anxiety Scale for Young Children
por: Ganley, Colleen M., et al.
Publicado: (2016)

P02.74. Treating Generalized Anxiety Disorder (GAD) using a self-care model of Complementary and Alternative Medicine (CAM) therapy
por: McPherson, F, et al.
Publicado: (2012)

Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings
por: Cardoso, João C. R., et al.
Publicado: (2020)

MECP2 duplication phenotype in symptomatic females: report of three further cases
por: Novara, Francesca, et al.
Publicado: (2014)

Altered neuronal network and rescue in a human MECP2 duplication model
por: Nageshappa, Savitha, et al.
Publicado: (2015)

IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced Inflammation
por: Gottschalk, Ilona, et al.
Publicado: (2022)

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function
por: Bajikar, Sameer S, et al.
Publicado: (2023)

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface
por: López, Cesar A., et al.
Publicado: (2017)

Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome
por: Ward, Christopher S., et al.
Publicado: (2016)

The Combined Dexamethasone/CRH Test (DEX/CRH Test) and Prediction of Acute Treatment Response in Major Depression
por: Schüle, Cornelius, et al.
Publicado: (2009)

Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
por: Raman, Ayush T., et al.
Publicado: (2018)

Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types
por: Salimando, Gregory J., et al.
Publicado: (2023)

Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
por: Zhang, Dinghong, et al.
Publicado: (2017)

MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα
por: Wang, Yu-Meng, et al.
Publicado: (2021)

MECP2 duplication syndrome: The electroclinical features of a case with long-term evolution
por: Cani, Ilaria, et al.
Publicado: (2022)

A brief history of MECP2 duplication syndrome: 20-years of clinical understanding
por: Ta, Daniel, et al.
Publicado: (2022)

MECP2 duplication syndrome initially misdiagnosed as cerebral palsy: a case report
por: Kim, Tae-Yong, et al.
Publicado: (2023)

How Families Manage the Complex Medical Needs of Their Children with MECP2 Duplication Syndrome
por: John Cherian, Dani, et al.
Publicado: (2023)

THU030 Evaluation Of Combined CRH And HDDST Test Performance
por: Elenius, Henrik, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8j1ahssdpvgt3baop0oshj8f3i