Rett Syndrome Mutation MeCP2 T158A Disrupts DNA Binding, Protein Stability and ERP Responses

Mutations in the MECP2 gene cause the autism spectrum disorder Rett Syndrome (RTT). One of the most common mutations associated with RTT occurs at MeCP2 Threonine 158 converting it to Methionine (T158M) or Alanine (T158A). To understand the role of T158 mutation in the pathogenesis of RTT, we genera...

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Detalles Bibliográficos
Autores principales: Goffin, Darren, Allen, Megan, Zhang, Le, Amorim, Maria, Wang, I-Ting Judy, Reyes, Arith-Ruth S., Mercado-Berton, Amy, Ong, Caroline, Cohen, Sonia, Hu, Linda, Blendy, Julie A., Carlson, Gregory C., Siegel, Steve J., Greenberg, Michael E., Zhou, Zhaolan (Joe)
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267879/
https://www.ncbi.nlm.nih.gov/pubmed/22119903
http://dx.doi.org/10.1038/nn.2997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267879/
https://www.ncbi.nlm.nih.gov/pubmed/22119903
http://dx.doi.org/10.1038/nn.2997

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