Frequent somatic MAP3K5 and MAP3K9 mutations in metastatic melanoma identified by exome sequencing

We sequenced 8 melanoma exomes to identify novel somatic mutations in metastatic melanoma. Focusing on the MAP3K family, we found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 or MAP3K9. Structural modelling predicts that mutations in the kinase domain...

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Detalles Bibliográficos
Autores principales: Stark, Mitchell S, Woods, Susan L, Gartside, Michael G, Bonazzi, Vanessa F, Dutton-Regester, Ken, Aoude, Lauren G, Chow, Donald, Sereduk, Chris, Niemi, Natalie M, Tang, Nanyun, Ellis, Jonathan J, Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M, Pollak, Thomas, Youngkin, David, Brooks, Bradford R, Lanagan, Catherine, Schmidt, Christopher W, Kobe, Bostjan, MacKeigan, Jeffrey P, Yin, Hongwei, Brown, Kevin M, Gibbs, Richard, Trent, Jeffrey, Hayward, Nicholas K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267896/
https://www.ncbi.nlm.nih.gov/pubmed/22197930
http://dx.doi.org/10.1038/ng.1041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267896/
https://www.ncbi.nlm.nih.gov/pubmed/22197930
http://dx.doi.org/10.1038/ng.1041

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