Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop

BACKGROUND AND PURPOSE: The cysteine-rich head region, which is adjacent to the proposed ATP-binding pocket in the extracellular ligand-binding loop of P2X receptors for ATP, is absent in the antagonist-insensitive Dictyostelium receptors. In this study we have determined the contribution of the hea...

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Detalles Bibliográficos
Autores principales: El-Ajouz, S, Ray, D, Allsopp, RC, Evans, RJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268193/
https://www.ncbi.nlm.nih.gov/pubmed/21671897
http://dx.doi.org/10.1111/j.1476-5381.2011.01534.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268193/
https://www.ncbi.nlm.nih.gov/pubmed/21671897
http://dx.doi.org/10.1111/j.1476-5381.2011.01534.x

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