Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

The PI3K (phosphoinositide 3-kinase) pathway is commonly activated in cancer as a consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10), a major negative regulator of PI3K signalling. In line with this important role of PTEN, mice that...

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Detalles Bibliográficos
Autores principales: Berenjeno, Inma M., Guillermet-Guibert, Julie, Pearce, Wayne, Gray, Alexander, Fleming, Stewart, Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268223/
https://www.ncbi.nlm.nih.gov/pubmed/22150431
http://dx.doi.org/10.1042/BJ20111741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268223/
https://www.ncbi.nlm.nih.gov/pubmed/22150431
http://dx.doi.org/10.1042/BJ20111741

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