Cargando…

Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats

Diabetes is a strong risk factor for premature and severe stroke. The GLP-1R (glucagon-like peptide-1 receptor) agonist Ex-4 (exendin-4) is a drug for the treatment of T2D (Type 2 diabetes) that may also have neuroprotective effects. The aim of the present study was to determine the efficacy of Ex-4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Darsalia, Vladimer, Mansouri, Shiva, Ortsäter, Henrik, Olverling, Anna, Nozadze, Nino, Kappe, Camilla, Iverfeldt, Kerstin, Tracy, Linda M., Grankvist, Nina, Sjöholm, Åke, Patrone, Cesare
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268352/ https://www.ncbi.nlm.nih.gov/pubmed/22150224 http://dx.doi.org/10.1042/CS20110374

Ejemplares similares

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride
por: Darsalia, Vladimer, et al.
Publicado: (2013)

GLP-1 secretion by microglial cells and decreased CNS expression in obesity
por: Kappe, Camilla, et al.
Publicado: (2012)

A High-Fat Diet Increases Activation of the Glucagon-Like Peptide-1-Producing Neurons in the Nucleus Tractus Solitarii: an Effect that is Partially Reversed by Drugs Normalizing Glycemia
por: Lietzau, Grazyna, et al.
Publicado: (2021)

Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice
por: Ortsäter, Henrik, et al.
Publicado: (2012)

Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2 Polarization
por: Darsalia, Vladimer, et al.
Publicado: (2014)

The high need for trials assessing functional outcome after stroke rather than stroke prevention with GLP-1 agonists and DPP-4 inhibitors
por: Darsalia, Vladimer, et al.
Publicado: (2018)

Western Diet Accelerates the Impairment of Odor-Related Learning and Olfactory Memory in the Mouse
por: Lietzau, Grazyna, et al.
Publicado: (2020)

Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4
por: Lietzau, Grazyna, et al.
Publicado: (2016)

The Stroke-Induced Increase of Somatostatin-Expressing Neurons is Inhibited by Diabetes: A Potential Mechanism at the Basis of Impaired Stroke Recovery
por: Chiazza, Fausto, et al.
Publicado: (2020)

Dipeptidyl Peptidase-4 Inhibitors for the Potential Treatment of Brain Disorders; A Mini-Review With Special Focus on Linagliptin and Stroke
por: Darsalia, Vladimer, et al.
Publicado: (2019)

The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway
por: Chiazza, Fausto, et al.
Publicado: (2018)

The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia–reperfusion brain injury in mice
por: Hammarlund, Maria E., et al.
Publicado: (2021)

Estimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study
por: Zabala, Alexander, et al.
Publicado: (2021)

DPP-4 Inhibitor and Sulfonylurea Differentially Reverse Type 2 Diabetes–Induced Blood–Brain Barrier Leakage and Normalize Capillary Pericyte Coverage
por: Elabi, Osama F., et al.
Publicado: (2023)

Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cells
por: Kappe, Camilla, et al.
Publicado: (2014)

Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4
por: Larsson, Martin, et al.
Publicado: (2016)

Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke
por: Karampatsi, Dimitra, et al.
Publicado: (2021)

The Pre-Stroke Induction and Normalization of Insulin Resistance Respectively Worsens and Improves Functional Recovery
por: Vercalsteren, Ellen, et al.
Publicado: (2023)

Liraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome
por: Fransson, Liselotte, et al.
Publicado: (2014)

Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin
por: Lietzau, Grazyna, et al.
Publicado: (2018)

Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice
por: Augestad, Ingrid Lovise, et al.
Publicado: (2021)

PACAP Protects Adult Neural Stem Cells from the Neurotoxic Effect of Ketamine Associated with Decreased Apoptosis, ER Stress and mTOR Pathway Activation
por: Mansouri, Shiva, et al.
Publicado: (2017)

Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu
por: Mansouri, Shiva, et al.
Publicado: (2016)

Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning
por: Basalay, Marina V., et al.
Publicado: (2016)

Exposure to the saturated free fatty acid palmitate alters microglia inflammatory response
por: Tracy, Linda, et al.
Publicado: (2013)

Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy
por: Lundberg, Mathias, et al.
Publicado: (2020)

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)
por: Jacobsen, Kristin, et al.
Publicado: (2013)

The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
por: Ramberg, Veronica, et al.
Publicado: (2011)

Regulation of Fe65 during neuronal differentiation
por: Koistinen, Niina, et al.
Publicado: (2013)

Urinary Analysis of Fluid Retention in the General Population: A Cross-Sectional Study
por: Hahn, Robert G., et al.
Publicado: (2016)

Liraglutide Therapy for Type 2 Diabetes: Overcoming Unmet Needs
por: Sjöholm, Åke
Publicado: (2010)

Atypical diabetes: a diagnostic challenge
por: Sjöholm, Åke
Publicado: (2020)

Ketosis-Prone Type 2 Diabetes: A Case Series
por: Sjöholm, Åke
Publicado: (2019)

GAD‐65 antibodies in a case of HNF1A‐Maturity‐Onset Diabetes of the Young: Double diabetes?
por: Sjöholm, Åke
Publicado: (2021)

Real Time Monitoring of Apoptosis, Induced by Beta-Amyloid Peptide, in SH-SY5Y Neuroblastoma Cells Expressing a GFP-Tagged Nuclear Pore Protein
por: Holmlund, Linda, et al.
Publicado: (2001)

Current Therapies for Neonatal Hypoxic–Ischaemic and Infection-Sensitised Hypoxic–Ischaemic Brain Damage
por: Tetorou, Konstantina, et al.
Publicado: (2021)

Glucagon Receptor Signaling and Glucagon Resistance
por: Janah, Lina, et al.
Publicado: (2019)

Refining prediction of major bleeding on antiplatelet treatment after transient ischaemic attack or ischaemic stroke
por: Hilkens, Nina A, et al.
Publicado: (2020)

The ischaemic constellation: an alternative to the ischaemic cascade—implications for the validation of new ischaemic tests
por: Maznyczka, Annette, et al.
Publicado: (2015)

Sodium-glucose cotransporter-2 inhibition and the insulin: Glucagon ratio: Unexplored dimensions
por: Kalra, Sanjay, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_shui98sl0im2dagkagdp8lhv8m