A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines

In this study, a completely water soluble tri-cationic porphyrin–EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy(3)PhenEDTA-P-Cl(4) in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SH...

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Autores principales: Schwach, Gert, Thamyongkit, Patchanita, Reith, Lorenz Michael, Svejda, Bernhard, Knör, Günther, Pfragner, Roswitha, Schoefberger, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268353/
https://www.ncbi.nlm.nih.gov/pubmed/22024042
http://dx.doi.org/10.1016/j.bioorg.2011.09.006
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author Schwach, Gert
Thamyongkit, Patchanita
Reith, Lorenz Michael
Svejda, Bernhard
Knör, Günther
Pfragner, Roswitha
Schoefberger, Wolfgang
author_facet Schwach, Gert
Thamyongkit, Patchanita
Reith, Lorenz Michael
Svejda, Bernhard
Knör, Günther
Pfragner, Roswitha
Schoefberger, Wolfgang
author_sort Schwach, Gert
collection PubMed
description In this study, a completely water soluble tri-cationic porphyrin–EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy(3)PhenEDTA-P-Cl(4) in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue and the results are compared to the tumor cell lines.
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spelling pubmed-32683532012-02-01 A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines Schwach, Gert Thamyongkit, Patchanita Reith, Lorenz Michael Svejda, Bernhard Knör, Günther Pfragner, Roswitha Schoefberger, Wolfgang Bioorg Chem Article In this study, a completely water soluble tri-cationic porphyrin–EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy(3)PhenEDTA-P-Cl(4) in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue and the results are compared to the tumor cell lines. Elsevier 2012-02 /pmc/articles/PMC3268353/ /pubmed/22024042 http://dx.doi.org/10.1016/j.bioorg.2011.09.006 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Article
Schwach, Gert
Thamyongkit, Patchanita
Reith, Lorenz Michael
Svejda, Bernhard
Knör, Günther
Pfragner, Roswitha
Schoefberger, Wolfgang
A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines
title A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines
title_full A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines
title_fullStr A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines
title_full_unstemmed A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines
title_short A water soluble tri-cationic porphyrin–EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines
title_sort water soluble tri-cationic porphyrin–edta conjugate induces apoptosis in human neuroendocrine tumor cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268353/
https://www.ncbi.nlm.nih.gov/pubmed/22024042
http://dx.doi.org/10.1016/j.bioorg.2011.09.006
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