Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

The aggresome pathway is activated when proteasomal clearance of misfolded proteins is hindered. Misfolded polyubiquitinated protein aggregates are recruited and transported to the aggresome via the microtubule network by a protein complex consisting of histone deacetylase 6 (HDAC6) and the dynein m...

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Detalles Bibliográficos
Autores principales: Ouyang, Hui, Ali, Yousuf O., Ravichandran, Mani, Dong, Aiping, Qiu, Wei, MacKenzie, Farrell, Dhe-Paganon, Sirano, Arrowsmith, Cheryl H., Zhai, R. Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268394/
https://www.ncbi.nlm.nih.gov/pubmed/22069321
http://dx.doi.org/10.1074/jbc.M111.273730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268394/
https://www.ncbi.nlm.nih.gov/pubmed/22069321
http://dx.doi.org/10.1074/jbc.M111.273730

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