Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

Hepatic insulin resistance has been attributed to both increased endoplasmic reticulum (ER) stress and accumulation of intracellular lipids, specifically diacylglycerol (DAG). The ER stress response protein, X-box-binding protein-1 (XBP1), was recently shown to regulate hepatic lipogenesis, suggesti...

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Detalles Bibliográficos
Autores principales: Jurczak, Michael J., Lee, Ann-Hwee, Jornayvaz, Francois R., Lee, Hui-Young, Birkenfeld, Andreas L., Guigni, Blas A., Kahn, Mario, Samuel, Varman T., Glimcher, Laurie H., Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268415/
https://www.ncbi.nlm.nih.gov/pubmed/22128176
http://dx.doi.org/10.1074/jbc.M111.316760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268415/
https://www.ncbi.nlm.nih.gov/pubmed/22128176
http://dx.doi.org/10.1074/jbc.M111.316760

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