Cargando…

A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival

BACKGROUND: Smad4 is the common mediator of the tumor suppressive functions of TGF-beta. Smad6 and Smad7 are the antagonists of the TGF-beta pathway. This study investigates the differential protein expressions of Smad4, Smad6 and Smad7 in tumor as compared to normal tissue of pancreatic ductal aden...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Puneet, Srinivasan, Radhika, Wig, Jai Dev, Radotra, Bishan Das
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268768/ https://www.ncbi.nlm.nih.gov/pubmed/22195733 http://dx.doi.org/10.1186/1756-0500-4-560

Ejemplares similares

Clinicopathological significance of SMAD4 loss in pancreatic ductal adenocarcinomas: a systematic review and meta-analysis
por: Wang, Jin-Dao, et al.
Publicado: (2016)

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma
por: Dardare, Julie, et al.
Publicado: (2020)

Alterations of tumor suppressor gene p16(INK4a )in pancreatic ductal carcinoma
por: Attri, Jyotika, et al.
Publicado: (2005)

SMAD4 Loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells
por: Chen, Yu-Wen, et al.
Publicado: (2014)

MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3
por: Wang, Chunyou, et al.
Publicado: (2016)

The Role of SMAD4 Inactivation in Epithelial–Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link?
por: Racu, Marie-Lucie, et al.
Publicado: (2022)

The Smads
por: Attisano, Liliana, et al.
Publicado: (2001)

It’s a SMAD, SMAD World: Cell Type–Specific SMAD Signaling in the Heart
por: Bradshaw, Amy D.
Publicado: (2019)

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
por: Liu, Nannan, et al.
Publicado: (2020)

Smad1 Expression in Follicular Lymphoma
por: Go, Jai Hyang
Publicado: (2015)

Clinicopathological characterization of SMAD4-mutated intestinal adenocarcinomas: A case-control study
por: Liao, Xiaoyan, et al.
Publicado: (2019)

SMAD4 Positive Pancreatic Ductal Adenocarcinomas Are Associated with Better Outcomes in Patients Receiving FOLFIRINOX-Based Neoadjuvant Therapy
por: Racu, Marie-Lucie, et al.
Publicado: (2023)

The DPC4/SMAD4 genetic status determines recurrence patterns and treatment outcomes in resected pancreatic ductal adenocarcinoma: A prospective cohort study
por: Shin, Sang Hyun, et al.
Publicado: (2017)

SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
por: Walldén, Karin, et al.
Publicado: (2017)

Correction: Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5.
por: Wei, Chang-Yong, et al.
Publicado: (2021)

Correction: Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5
por: Wei, Chang-Yong, et al.
Publicado: (2021)

Expression and Polymorphisms of SMAD1, SMAD2 and SMAD3 Genes and Their Association with Litter Size in Tibetan Sheep (Ovis aries)
por: Li, Mingming, et al.
Publicado: (2022)

Agmatinase facilitates the tumorigenesis of pancreatic adenocarcinoma through the TGFβ/Smad pathway
por: Zhang, Yue, et al.
Publicado: (2022)

Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma
por: Hsieh, Yao-Yu, et al.
Publicado: (2019)

Smad signalling in the ovary
por: Kaivo-oja, Noora, et al.
Publicado: (2006)

Clinical impacts of resection margin status and clinicopathologic parameters on pancreatic ductal adenocarcinoma
por: Jamiyan, Tsengelmaa, et al.
Publicado: (2020)

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate
por: Wang, Weiguang, et al.
Publicado: (2016)

Roles of Smads Family and Alternative Splicing Variants of Smad4 in Different Cancers
por: Ullah, Irfan, et al.
Publicado: (2018)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Molecular Characterization, Expression Profiles of SMAD4, SMAD5 and SMAD7 Genes and Lack of Association with Litter Size in Tibetan Sheep
por: Sun, Ruizhe, et al.
Publicado: (2022)

Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma
por: Yoo, Seung-Yeon, et al.
Publicado: (2019)

SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal Epithelium
por: Kang, Ya'an, et al.
Publicado: (2014)

Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only
por: Ottenhof, Niki A., et al.
Publicado: (2012)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas
por: Liu, Chunhui, et al.
Publicado: (2016)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Deep learning for de-convolution of Smad2 versus Smad3 binding sites
por: Ng, Jeremy W.K., et al.
Publicado: (2022)

Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients
por: Mangone, Flavia RR, et al.
Publicado: (2010)

Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling
por: Seyhan, H, et al.
Publicado: (2006)

High SMAD7 and p-SMAD2,3 expression is associated with environmental enteropathy in children
por: Syed, Sana, et al.
Publicado: (2018)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia
por: Brkić, Jelena, et al.
Publicado: (2020)

Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling
por: Wu, Jian, et al.
Publicado: (2021)

Combination immunohistochemistry for SMAD4 and Runt-related transcription factor 3 may identify a favorable prognostic subgroup of pancreatic ductal adenocarcinomas
por: Lee, Yangkyu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g7keupnm501grkc0eecv76q5f3