The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

BACKGROUND: The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD). Clinical development of BACE1 inhibitors is being intensely pursued. However, little is known about the...

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Detalles Bibliográficos
Autores principales: Rajapaksha, Tharinda W, Eimer, William A, Bozza, Thomas C, Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269394/
https://www.ncbi.nlm.nih.gov/pubmed/22204380
http://dx.doi.org/10.1186/1750-1326-6-88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269394/
https://www.ncbi.nlm.nih.gov/pubmed/22204380
http://dx.doi.org/10.1186/1750-1326-6-88

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