Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo- and positive-controlled thorough QT study

AIMS: To assess steady-state effects of therapeutic and supra-therapeutic doses of prucalopride on the QT interval using a novel design involving a parallel placebo group with nested crossover for positive control. METHODS: A double-blind, double-dummy, placebo- and active-controlled study was condu...

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Detalles Bibliográficos
Autores principales: Mendzelevski, Boaz, Ausma, Jannie, Chanter, Dennis O, Robinson, Patricia, Kerstens, Rene, Vandeplassche, Lieve, Camm, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2012
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269579/
https://www.ncbi.nlm.nih.gov/pubmed/21848574
http://dx.doi.org/10.1111/j.1365-2125.2011.04088.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269579/
https://www.ncbi.nlm.nih.gov/pubmed/21848574
http://dx.doi.org/10.1111/j.1365-2125.2011.04088.x

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